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to maintain the shape of the eye, to cover surgical instruments and to protect the corneal endothelium from damage. Hydrogels of sodium hyaluronate have been used for many years in ophthalmic surgery in Europe and the U.S. To further maximize patient comfort, the pH of VISMED® is adjusted to 7.3, similar to that of the natural tear film. Some preservatives are known to cause toxic or allergic reactions, the symptoms of which include stinging, burning and redness of the eyes. without causing superficial punctate keratitis). As a result, it is non-irritating to ocular tissues and can be used frequently and for extended periods without harming the surface of the eye (e.g. VISMED® is completely free of preservatives. This, together with the coating properties of sodium hyaluronate, results in an increased pre-corneal residence time and tear film break-up time (BUT) and therefore longer lubrication of the eye surface. Sodium hyaluronate also possesses mucoadhesive properties and the ability to entrap water, thus resembling tear mucus glycoprotein. It is believed that this protective coating of the surface of the eye helps prevent dryness and irritation. This means that VISMED® has a high viscosity between blinks and a low viscosity during blinking ensuring efficient coating of the surface of the eye.
Its main physical characteristic is viscoelasticity. Sodium hyaluronate is a natural polymer which is also present in the structures of the human eye. The proprietary formulation contains a highly purified specific fraction of sodium hyaluronate. VISMED® is currently marketed in Europe under the CE mark as a viscoelastic lubricant eye drop.
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Our facility conducts Phase II-IV clinical trials. Our research team consist of a group of Board Certified OB-GYN and Internal Medicine Investigators, Physician Assistant, ACRP Certified Clinical Research Coordinators, Quality Assurance Specialist (ACRP Certified) and Data Entry Specialist. CHATTANOOGA MEDICAL RESEARCH, LLC (CMR) CMR is a privately owned multi-specialty clinical research facility.
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